NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

The presence of genomic alterations in cancer associated fibroblasts (CAFs) is largely unexplored. The authors show that frequent NOTCH1 gene amplification and overexpression render CAFs resistant to the UVA-induced DNA damage response (DDR) and promote cancer/stromal cells expansion, which can be r...

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Bibliographic Details
Main Authors: Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18919-2

Internet

https://doi.org/10.1038/s41467-020-18919-2

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