Cloning and expression of <it>R-Spondin1 </it>in different vertebrates suggests a conserved role in ovarian development

Cloning and expression of <it>R-Spondin1 </it>in different vertebrates suggests a conserved role in ovarian development

<p>Abstract</p> <p>Background</p> <p>R-Spondin1 (Rspo1) is a novel regulator of the Wnt/β-catenin signalling pathway. Loss-of-function mutations in human <it>RSPO1 </it>cause testicular differentiation in 46, XX females, pointing to a role in ovarian develop...

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Bibliographic Details
Main Authors: Crews David, Queen Joanna, Roeszler Kelly N, Shoemaker Christina M, Smith Craig A, Sinclair Andrew H
Format: Article
Language:English
Published: BMC 2008-07-01
Series:BMC Developmental Biology
Online Access:http://www.biomedcentral.com/1471-213X/8/72

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