Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment

Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment

Abstract Accumulating evidence suggests that the lesions of Parkinson’s disease (PD) expand due to transneuronal spreading of fibrils composed of misfolded alpha-synuclein (a-syn), over the course of 5–10 years. However, the precise mechanisms and the processes underlying the spread of these fibril...

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Bibliographic Details
Main Authors: Ayami Okuzumi, Masaru Kurosawa, Taku Hatano, Masashi Takanashi, Shuuko Nojiri, Takeshi Fukuhara, Tomoyuki Yamanaka, Haruko Miyazaki, Saki Yoshinaga, Yoshiaki Furukawa, Tomomi Shimogori, Nobutaka Hattori, Nobuyuki Nukina
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Acta Neuropathologica Communications
Subjects:
Rapid dissemination
A-syn
Propagation
Callosotomy
Online Access:http://link.springer.com/article/10.1186/s40478-018-0587-0

Internet

http://link.springer.com/article/10.1186/s40478-018-0587-0

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