Tox21Challenge to build predictive models of nuclear receptor and stress response pathways as mediated by exposure to environmental chemicals and drugs

Tox21Challenge to build predictive models of nuclear receptor and stress response pathways as mediated by exposure to environmental chemicals and drugs

Tens of thousands of chemicals with poorly understood biological properties are released into the environment each day. High-throughput screening (HTS) is potentially a more efficient and cost-effective alternative to traditional toxicity tests. Using HTS, one can profile chemicals for potential ad...

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Bibliographic Details
Main Authors: Ruili eHuang, Menghang eXia, Dac-Trung eNguyen, Tongan eZhao, Srilatha eSakamuru, Jinghua eZhao, Sampada A Shahane, Anna eRossoshek, Anton eSimeonov
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Environmental Science
Subjects:
nuclear receptor
QSAR
stress response
HTS
in vitro assay
predictive model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fenvs.2015.00085/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fenvs.2015.00085/full

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