Cell stress induces upregulation of osteopontin via the ERK pathway in type II alveolar epithelial cells.

Cell stress induces upregulation of osteopontin via the ERK pathway in type II alveolar epithelial cells.

Osteopontin (OPN) is a multifunctional protein that plays important roles in cell growth, differentiation, migration and tissue fibrosis. In human idiopathic pulmonary fibrosis and murine bleomycin-induced lung fibrosis, OPN is upregulated in type II alveolar epithelial cells (AEC II). However, the...

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Bibliographic Details
Main Authors: Aki Kato, Takafumi Okura, Chizuru Hamada, Seigo Miyoshi, Hitoshi Katayama, Jitsuo Higaki, Ryoji Ito
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4070890?pdf=render

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http://europepmc.org/articles/PMC4070890?pdf=render

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