The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner

A well-controlled innate immune response is characterized by a rapid yet self-limiting inflammatory response. Although much is known about the range of inflammatory stimuli capable of triggering an innate immune response, the mechanisms which govern the degree of inflammation induced by inflammatory...

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Bibliographic Details
Main Authors: Joseph Skurski, Garima Dixit, Carl P. Blobel, Priya D. Issuree, Thorsten Maretzky
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.620392/full