Pattern Recognition Techniques Applied to the Study of Leishmanial Glyceraldehyde-3-Phosphate Dehydrogenase Inhibition

Pattern Recognition Techniques Applied to the Study of Leishmanial Glyceraldehyde-3-Phosphate Dehydrogenase Inhibition

Chemometric pattern recognition techniques were employed in order to obtain Structure-Activity Relationship (SAR) models relating the structures of a series of adenosine compounds to the affinity for glyceraldehyde 3-phosphate dehydrogenase of Leishmania mexicana (LmGAPDH). A training set of 49 comp...

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Bibliographic Details
Main Authors: Norka B. H. Lozano, Rafael F. Oliveira, Karen C. Weber, Kathia M. Honorio, Rafael V. C. Guido, Adriano D. Andricopulo, Alexsandro G. de Sousa, Albérico B. F. da Silva
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
pattern recognition
adenosine compounds
glyceraldehyde 3-phosphate dehydrogenase
antileishmanial activity
Online Access:http://www.mdpi.com/1422-0067/15/2/3186

Internet

http://www.mdpi.com/1422-0067/15/2/3186

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