The Drug Candidate BGP-15 Delays the Onset of Diastolic Dysfunction in the Goto-Kakizaki Rat Model of Diabetic Cardiomyopathy

The Drug Candidate BGP-15 Delays the Onset of Diastolic Dysfunction in the Goto-Kakizaki Rat Model of Diabetic Cardiomyopathy

<i>Background and Aims</i>: Diabetic cardiomyopathy (DCM) is an emerging problem worldwide due to an increase in the incidence of type 2 diabetes. Animal studies have indicated that metformin and pioglitazone can prevent DCM partly by normalizing insulin resistance, and partly by other,...

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Bibliographic Details
Main Authors: Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Rita Kiss, Nora Hollos, Balazs Varga, Jozsef Nemeth, Attila Toth, Zoltan Papp, Zoltan Szilvassy, Bela Juhasz
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
diastolic dysfunction
type 2 diabetes
Goto-Kakizaki
BGP-15
metformin
pioglitazone
echocardiography
endothelial dysfunction
Online Access:https://www.mdpi.com/1420-3049/24/3/586

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https://www.mdpi.com/1420-3049/24/3/586

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