Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.

Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.

Pyruvate carboxylase (PC) is an anaplerotic enzyme that regulates glucose-induced insulin secretion in pancreatic islets. Dysregulation of its expression is associated with type 2 diabetes. Herein we describe the molecular mechanism underlying the glucose-mediated transcriptional regulation of the P...

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Bibliographic Details
Main Authors: Apilak Wutthisathapornchai, Tuangtong Vongpipatana, Sureeporn Muangsawat, Thirajit Boonsaen, Michael J MacDonald, Sarawut Jitrapakdee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25054881/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25054881/pdf/?tool=EBI

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