Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period

Abstract Background Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous glutamatergic antagonist, was able to decrease the expression of pituitary adenylate cyclase-activating poly...

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Main Authors: Bernadett Tuka, Aliz Nyári, Edina Katalin Cseh, Tamás Körtési, Dániel Veréb, Ferenc Tömösi, Gábor Kecskeméti, Tamás Janáky, János Tajti, László Vécsei
Format: Article
Language:English
Published: BMC 2021-06-01
Series:The Journal of Headache and Pain
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Online Access:https://doi.org/10.1186/s10194-021-01239-1