PPAR-γ promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3

PPAR-γ promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3

Abstract Background Ischemia-reperfusion (I/R)-induced vascular dysfunction is the main factor to acute ischemic stroke. Sirt3 is one of the sirtuin family members, which plays an important role in the development of neurological diseases. Methods In this study, we constructed I/R injury model on HB...

Full description

Bibliographic Details
Main Authors: Zhenzhen Zhao, Xiaoxiu Zhang, Yuanqiang Dai, Ke Pan, Yu Deng, Yan Meng, Tao Xu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Neurology
Subjects:
PPAR-γ
p38
Sirt3
Cell permeability
Ischemia-reperfusion
Online Access:http://link.springer.com/article/10.1186/s12883-019-1508-y

Internet

http://link.springer.com/article/10.1186/s12883-019-1508-y

Similar Items