Thiazide-associated hyponatremia attenuates the fracture-protective effect of thiazide: A population-based study.

<h4>Background</h4>Thiazide, a first-line therapy for hypertension, lowers blood pressure, increases bone mineral density, and reduces the risk of fractures. However, hyponatremia, an adverse effect of thiazide, is associated with increased risk of osteoporosis and fractures. It is curre...

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Bibliographic Details
Main Authors: Lii-Jia Yang, Ping-Hsun Wu, Teng-Hui Huang, Ming-Yen Lin, Jer-Chia Tsai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0208712