Heparin impairs skeletal muscle glucose uptake by inhibiting insulin binding to insulin receptor

Heparin impairs skeletal muscle glucose uptake by inhibiting insulin binding to insulin receptor

Abstract Aim Heparin, a widely used antithrombotic drug has many other anticoagulant‐independent physiological functions. Here, we elucidate a novel role of heparin in glucose homeostasis, suggesting an approach for developing heparin‐targeted therapies for diabetes. Methods For serum heparin levels...

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Bibliographic Details
Main Authors: Canjun Zhu, Zhiyue Xu, Yexian Yuan, Tao Wang, Chang Xu, Cong Yin, Peipei Xie, Pingwen Xu, Hui Ye, Nirali Patel, Sarah Schaul, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Qianyun Xi, Yongliang Zhang, Gang Shu, Qingyan Jiang
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Endocrinology, Diabetes & Metabolism
Subjects:
GLUT4 activity
heparin
hyperglycaemia
insulin resistance
muscle glucose uptake
Online Access:https://doi.org/10.1002/edm2.253

Internet

https://doi.org/10.1002/edm2.253

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