A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity

Neurotransmitter release probability (Pr) largely determines the dynamic properties of synapses. While much is known about the role of presynaptic proteins in transmitter release, their specific contribution to synaptic plasticity is unclear. One such protein, tomosyn, is believed to reduce Pr by in...

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Bibliographic Details
Main Authors: Yoav Ben-Simon, Alma Rodenas-Ruano, Karina Alviña, Alice D. Lam, Edward L. Stuenkel, Pablo E. Castillo, Uri Ashery
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471500649X