Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

Abstract Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation. On the other hand, RNA interference (RNAi)-based targeted gene silencing is...

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Bibliographic Details
Main Authors: Egle-Helene Ervin, Martin Pook, Indrek Teino, Valmar Kasuk, Annika Trei, Margus Pooga, Toivo Maimets
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Stem Cell Research & Therapy
Subjects:
Human embryonic stem cells
siRNA transfection
Cell-penetrating peptide
PepFect 14
OCT4
B2M
Online Access:http://link.springer.com/article/10.1186/s13287-019-1144-x

Internet

http://link.springer.com/article/10.1186/s13287-019-1144-x

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