Haplotype-resolved germline and somatic alterations in renal medullary carcinomas

Haplotype-resolved germline and somatic alterations in renal medullary carcinomas

Abstract Background Renal medullary carcinomas (RMCs) are rare kidney cancers that occur in adolescents and young adults of African ancestry. Although RMC is associated with the sickle cell trait and somatic loss of the tumor suppressor, SMARCB1, the ancestral origins of RMC remain unknown. Further,...

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Bibliographic Details
Main Authors: Kar-Tong Tan, Hyunji Kim, Jian Carrot-Zhang, Yuxiang Zhang, Won Jun Kim, Guillaume Kugener, Jeremiah A. Wala, Thomas P. Howard, Yueh-Yun Chi, Rameen Beroukhim, Heng Li, Gavin Ha, Seth L. Alper, Elizabeth J. Perlman, Elizabeth A. Mullen, William C. Hahn, Matthew Meyerson, Andrew L. Hong
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Genome Medicine
Subjects:
Linked-read sequencing
Haplotypes
Renal medullary carcinoma
Sickle cell trait
Online Access:https://doi.org/10.1186/s13073-021-00929-4

Internet

https://doi.org/10.1186/s13073-021-00929-4

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