Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma

Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma

Abstract Background Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disease. Some children with OMS also have neuroblastoma (NB). We and others have previously documented that serum IgG from children with OMS and NB induces neuronal cytolysis and activates several signaling pathways. Howe...

Full description

Bibliographic Details
Main Authors: Xu Ding, Wei Yang, Qinghua Ren, Jiajian Hu, Shen Yang, Wei Han, Jing Wang, Xu Wang, Huanmin Wang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Opsoclonus-myoclonus syndrome
Neuroblastoma
Children
Microglial activation
Nitric oxide (NO)
Soluble guanylyl cyclase (sGC)
Online Access:http://link.springer.com/article/10.1186/s12974-020-01839-9

Internet

http://link.springer.com/article/10.1186/s12974-020-01839-9

Similar Items