Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog.

The human cylindromatosis tumor suppressor (HsCyld) has attracted extensive attention due to its association with the development of multiple types of cancer. HsCyld encodes a deubiquitinating enzyme (HsCYLD) with a broad range of functions that include the regulation of several cell growth, differe...

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Bibliographic Details
Main Authors: Paul Hadweh, Iro Chaitoglou, Maria Joao Gravato-Nobre, Petros Ligoxygakis, George Mosialos, Eudoxia Hatzivassiliou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5796713?pdf=render