Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study

Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study

Introduction: Disruptions of extracellular matrix (ECM) degradation homeostasis play a significant role in the pathogenesis of osteoarthritis (OA). Matrix metalloproteinase 13 (MMP13) and collagen Ⅱ are important components of ECM. Earlier we found that quercitrin could significantly decrease MMP13...

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Bibliographic Details
Main Authors: Hanli Guo, Weifeng Yin, Ziling Zou, Chao Zhang, Minghui Sun, Lingtian Min, Lei Yang, Lingyi Kong
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Journal of Advanced Research
Subjects:
Osteoarthritis
Quercitrin
Phosphatidylinositol 3-kinase p110α
Extracellular matrix degradation
MMP13
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220301296

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http://www.sciencedirect.com/science/article/pii/S2090123220301296

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