Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties

Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties

Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline structures including two new polymorphs of the pure drug and a series of cocrystals of PZQ have been discovered and deposited in the Cambridge Struc...

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Bibliographic Details
Main Authors: Debora Zanolla, Dritan Hasa, Mihails Arhangelskis, Gabriela Schneider-Rauber, Michele R. Chierotti, Jennifer Keiser, Dario Voinovich, William Jones, Beatrice Perissutti
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
praziquantel
hemihydrate
mechanochemistry
neat grinding
liquid-assisted grinding
racemic compound
polymorphism
crystal structure solution
Online Access:https://www.mdpi.com/1999-4923/12/3/289

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https://www.mdpi.com/1999-4923/12/3/289

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