Hypothalamic and Cell-Specific Transcriptomes Unravel a Dynamic Neuropil Remodeling in Leptin-Induced and Typical Pubertal Transition in Female Mice

Summary: Epidemiological and genome-wide association studies (GWAS) have shown high correlation between childhood obesity and advance in puberty. Early age at menarche is associated with a series of morbidities, including breast cancer, cardiovascular diseases, type 2 diabetes, and obesity. The adip...

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Bibliographic Details
Main Authors: Xingfa Han, Laura L. Burger, David Garcia-Galiano, Seokmin Sim, Susan J. Allen, David P. Olson, Martin G. Myers, Jr., Carol F. Elias
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307550