The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis

The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis

Ketoconazole is a clinically safe antifungal agent that also inhibits the growth of Leishmania spp. A study was undertaken to determine whether Leishmania parasites are prone to becoming resistant to ketoconazole by upregulating C14-demethylase after stepwise pharmacological pressure. Leishmania ama...

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Bibliographic Details
Main Authors: Valter Viana Andrade-Neto, Herbert Leonel de Matos-Guedes, Daniel Cláudio de Oliveira Gomes, Marilene Marcuzzo do Canto-Cavalheiro, Bartira Rossi-Bergmann, Eduardo Caio Torres-Santos
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2012-05-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
drug resistance
azoles
ergosterol biosynthesis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300018&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300018&lng=en&tlng=en

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