Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function.

Vacuolar-type H(+)-ATPases (V-ATPases) are macromolecular proton pumps that acidify intracellular cargos and deliver protons across the plasma membrane of a variety of specialized cells, including bone-resorbing osteoclasts. Extracellular acidification is crucial for osteoclastic bone resorption, a...

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Bibliographic Details
Main Authors: An Qin, Tak S Cheng, Zhen Lin, Nathan J Pavlos, Qing Jiang, Jiake Xu, Ke R Dai, Ming H Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22087256/pdf/?tool=EBI