Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases.

Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics. To discover new leads we designed an automated label-free, high content-based, high thro...

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Bibliographic Details
Main Authors: Ross A Paveley, Nuha R Mansour, Irene Hallyburton, Leo S Bleicher, Alex E Benn, Ivana Mikic, Alessandra Guidi, Ian H Gilbert, Andrew L Hopkins, Quentin D Bickle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3409125?pdf=render