RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NA...

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Main Authors: S. Piras, A. L. Furfaro, C. Domenicotti, N. Traverso, U. M. Marinari, M. A. Pronzato, M. Nitti
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/9348651
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spelling doaj-4fbb31d9044843478abdad98aab04f8b2020-11-24T21:01:29ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942016-01-01201610.1155/2016/93486519348651RAGE Expression and ROS Generation in Neurons: Differentiation versus DamageS. Piras0A. L. Furfaro1C. Domenicotti2N. Traverso3U. M. Marinari4M. A. Pronzato5M. Nitti6Department of Experimental Medicine, University of Genoa, Via L.B. Alberti 2, 16132 Genoa, ItalyGiannina Gaslini Institute, Via Gerolamo Gaslini 5, 16147 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B. Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B. Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B. Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B. Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B. Alberti 2, 16132 Genoa, ItalyRAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases. In neuronal cells, RAGE-induced ROS generation is able to favor cell survival and differentiation or to induce death through the imbalance of redox state. The dual nature of RAGE signaling in neurons depends not only on the intensity of RAGE activation but also on the ability of RAGE-bearing cells to adapt to ROS generation. In this review we highlight these aspects of RAGE signaling regulation in neuronal cells.http://dx.doi.org/10.1155/2016/9348651
collection DOAJ
language English
format Article
sources DOAJ
author S. Piras
A. L. Furfaro
C. Domenicotti
N. Traverso
U. M. Marinari
M. A. Pronzato
M. Nitti
spellingShingle S. Piras
A. L. Furfaro
C. Domenicotti
N. Traverso
U. M. Marinari
M. A. Pronzato
M. Nitti
RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
Oxidative Medicine and Cellular Longevity
author_facet S. Piras
A. L. Furfaro
C. Domenicotti
N. Traverso
U. M. Marinari
M. A. Pronzato
M. Nitti
author_sort S. Piras
title RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_short RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_full RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_fullStr RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_full_unstemmed RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_sort rage expression and ros generation in neurons: differentiation versus damage
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2016-01-01
description RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases. In neuronal cells, RAGE-induced ROS generation is able to favor cell survival and differentiation or to induce death through the imbalance of redox state. The dual nature of RAGE signaling in neurons depends not only on the intensity of RAGE activation but also on the ability of RAGE-bearing cells to adapt to ROS generation. In this review we highlight these aspects of RAGE signaling regulation in neuronal cells.
url http://dx.doi.org/10.1155/2016/9348651
work_keys_str_mv AT spiras rageexpressionandrosgenerationinneuronsdifferentiationversusdamage
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AT cdomenicotti rageexpressionandrosgenerationinneuronsdifferentiationversusdamage
AT ntraverso rageexpressionandrosgenerationinneuronsdifferentiationversusdamage
AT ummarinari rageexpressionandrosgenerationinneuronsdifferentiationversusdamage
AT mapronzato rageexpressionandrosgenerationinneuronsdifferentiationversusdamage
AT mnitti rageexpressionandrosgenerationinneuronsdifferentiationversusdamage
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