Atrial-selective block of sodium channels by acehytisine in rabbit myocardium

Atrial-selective block of sodium channels by acehytisine in rabbit myocardium

Acehytisine, a multi-ion channel blocker, can markedly inhibit INa, ICa, IKur, If at various concentrations and effectively terminate and prevent atrial fibrillation (AF) in patients and animal models, but the molecular mechanism underlying its blockage remains elusive. In this study, we investigate...

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Bibliographic Details
Main Authors: Xinrong Fan, Chao Wang, Na Wang, Xianhong Ou, Hanxiong Liu, Yan Yang, Xitong Dang, Xiaorong Zeng, Lin Cai
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Journal of Pharmacological Sciences
Subjects:
Acehytisine
Sodium channel
Atrial-selective
Atrial fibrillation
Patch-clamp
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300160

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http://www.sciencedirect.com/science/article/pii/S1347861316300160

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