Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib

Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib

The antitumorigenic mechanism of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib is still a matter of debate. Among different structurally related COX-2 inhibitors, only celecoxib was found to cause apoptosis and cell death of human lung cancer cells (IC50 values of 19.96 µM [A549], 12.48...

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Bibliographic Details
Main Authors: Robert Ramer, Udo Walther, Philipp Borchert, Stefan Laufer, Michael Linnebacher, Burkhard Hinz
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Journal of Lipid Research
Subjects:
prostaglandins
peroxisome proliferator activated receptor gamma
nonsteroidal antiinflammatory drugs
cyclooxygenase-2
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752035063X

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http://www.sciencedirect.com/science/article/pii/S002222752035063X

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