The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils

The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils

Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has proven to be controversial due to their relative rarity and their complex lineage phenotype. Here, we show that the expression of baso...

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Bibliographic Details
Main Authors: Christophe Pellefigues, Palak Mehta, Melanie Sarah Prout, Karmella Naidoo, Bibek Yumnam, Jodie Chandler, Sally Chappell, Kara Filbey, Mali Camberis, Graham Le Gros
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
basophil
Basoph8
depletion
flow cytometry
phenotype
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02143/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02143/full

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