Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution.

Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution.

Cells can adapt to hypoxia by various mechanisms. Yet, hypoxia-induced effects on the cytoskeleton-based cell architecture and functions are largely unknown. Here we present a comprehensive analysis of the architecture and function of L929 fibroblasts under hypoxic conditions (1% O2). Cells cultivat...

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Bibliographic Details
Main Authors: Melanie Vogler, Sabine Vogel, Sabine Krull, Katja Farhat, Pia Leisering, Susanne Lutz, Christina M Wuertz, Dörthe M Katschinski, Anke Zieseniss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3715466?pdf=render

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http://europepmc.org/articles/PMC3715466?pdf=render

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