Hakin-1, a New Specific Small-Molecule Inhibitor for the E3 Ubiquitin-Ligase Hakai, Inhibits Carcinoma Growth and Progression

Hakin-1, a New Specific Small-Molecule Inhibitor for the E3 Ubiquitin-Ligase Hakai, Inhibits Carcinoma Growth and Progression

The requirement of the E3 ubiquitin-ligase Hakai for the ubiquitination and subsequent degradation of E-cadherin has been associated with enhanced epithelial-to-mesenchymal transition (EMT), tumour progression and carcinoma metastasis. To date, most of the reported EMT-related inhibitors were not de...

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Bibliographic Details
Main Authors: Olaia Martinez-Iglesias, Alba Casas-Pais, Raquel Castosa, Andrea Díaz-Díaz, Daniel Roca-Lema, Ángel Concha, Álvaro Cortés, Federico Gago, Angélica Figueroa
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
anticancer therapy
small-molecule inhibitor
epithelial-to-mesenchymal transition (EMT)
E-cadherin
E3 ubiquitin-ligase
Hakai
Online Access:https://www.mdpi.com/2072-6694/12/5/1340

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https://www.mdpi.com/2072-6694/12/5/1340

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