Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clampe...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-01-01
|
| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319324223 |
| id |
doaj-4f48eff8c8d0459eb7a107526787efa6 |
|---|---|
| record_format |
Article |
| spelling |
doaj-4f48eff8c8d0459eb7a107526787efa62020-11-25T02:44:11ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-01953398401Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial NodeKentaro Takeda0Reiko Yamagishi1Haruko Masumiya2Hikaru Tanaka3Koki Shigenobu4Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, Japan; Corresponding author. FAX: +81-47-472-2113 E-mail: htanaka@phar.toho-u.ac.jpDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanCilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clamped guinea pig ventricular myocytes, cilnidipine concentration-dependently decreased L- and T-type Ca2+ currents. In rabbit sinoatrial node tissue, cilnidipine increased cycle length through reduction of phase 4 depolarization slope. In conclusion, cilnidipine has inhibitory effects on T-type Ca2+ current, which may contribute to its negative chronotropic potency. Keywords:: cilnidipine, T-type Ca2+ channel, cardiomyocytehttp://www.sciencedirect.com/science/article/pii/S1347861319324223 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kentaro Takeda Reiko Yamagishi Haruko Masumiya Hikaru Tanaka Koki Shigenobu |
| spellingShingle |
Kentaro Takeda Reiko Yamagishi Haruko Masumiya Hikaru Tanaka Koki Shigenobu Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node Journal of Pharmacological Sciences |
| author_facet |
Kentaro Takeda Reiko Yamagishi Haruko Masumiya Hikaru Tanaka Koki Shigenobu |
| author_sort |
Kentaro Takeda |
| title |
Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
| title_short |
Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
| title_full |
Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
| title_fullStr |
Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
| title_full_unstemmed |
Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
| title_sort |
effect of cilnidipine on l- and t-type calcium currents in guinea pig ventricle and action potential in rabbit sinoatrial node |
| publisher |
Elsevier |
| series |
Journal of Pharmacological Sciences |
| issn |
1347-8613 |
| publishDate |
2004-01-01 |
| description |
Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clamped guinea pig ventricular myocytes, cilnidipine concentration-dependently decreased L- and T-type Ca2+ currents. In rabbit sinoatrial node tissue, cilnidipine increased cycle length through reduction of phase 4 depolarization slope. In conclusion, cilnidipine has inhibitory effects on T-type Ca2+ current, which may contribute to its negative chronotropic potency. Keywords:: cilnidipine, T-type Ca2+ channel, cardiomyocyte |
| url |
http://www.sciencedirect.com/science/article/pii/S1347861319324223 |
| work_keys_str_mv |
AT kentarotakeda effectofcilnidipineonlandttypecalciumcurrentsinguineapigventricleandactionpotentialinrabbitsinoatrialnode AT reikoyamagishi effectofcilnidipineonlandttypecalciumcurrentsinguineapigventricleandactionpotentialinrabbitsinoatrialnode AT harukomasumiya effectofcilnidipineonlandttypecalciumcurrentsinguineapigventricleandactionpotentialinrabbitsinoatrialnode AT hikarutanaka effectofcilnidipineonlandttypecalciumcurrentsinguineapigventricleandactionpotentialinrabbitsinoatrialnode AT kokishigenobu effectofcilnidipineonlandttypecalciumcurrentsinguineapigventricleandactionpotentialinrabbitsinoatrialnode |
| _version_ |
1724766919921238016 |