Surface Adjustment of Reverse Phase Protein Arrays using Positive Control Spots

Reverse phase protein arrays (RPPA) measure the relative expression levels of a protein in many samples simultaneously. Observed signal from these arrays is a combination of true signal, additive background, and multiplicative spatial effects. Background subtraction alone is not sufficient to remove...

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Bibliographic Details
Main Authors: E. Shannon Neeley, Keith A. Baggerly, Steven M. Kornblau
Format: Article
Language:English
Published: SAGE Publishing 2012-01-01
Series:Cancer Informatics
Online Access:https://doi.org/10.4137/CIN.S9055