Genome instability and aging: Cause or effect?

Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal lineages, such as tumors, normal tissues have thus far not been amenable to mutation analysis except f...

Full description

Bibliographic Details
Main Authors: Jan Vijg, Cristina Montagna
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-10-01
Series:Translational Medicine of Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S246850111730010X