MHC class II-restricted epitopes containing an oxido-reductase activity prompt CD4+ T cells with apoptosis-inducing properties

MHC class II-restricted epitopes containing an oxido-reductase activity prompt CD4+ T cells with apoptosis-inducing properties

Abrogating an unwanted immune response towards a specific antigen without compromising the entire immune system is a hoped-for goal in immunotherapy. Instead of manipulating dendritic cells and suppressive regulatory T cells, depleting effector T cells or blocking their co-stimulatory pathways, we d...

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Bibliographic Details
Main Authors: Elin eMalek Abrahimians, Vincent eCarlier, Luc eVander Elst, Jean-Marie eSaint-Remy
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
Apoptosis
immune suppression
Oxido-reductase activity
MHC class II epitopes
cytolytic CD4+ T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00449/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00449/full

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