Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

5-Fluorouracil (5-FU) is an anticancer drug extensively used for different cancers. Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes, DNA and RNA. In this paper, we describ...

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Bibliographic Details
Main Authors: Christelle Machon, Frédéric Catez, Nicole Dalla Venezia, Floriane Vanhalle, Laetitia Guyot, Anne Vincent, Maxime Garcia, Béatrice Roy, Jean-Jacques Diaz, Jérôme Guitton
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Journal of Pharmaceutical Analysis
Subjects:
5-Fluorouracil
LC-MS-HRMS
Nucleotide
RNA
DNA
Incorporation rate
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177919308676

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http://www.sciencedirect.com/science/article/pii/S2095177919308676

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