Divergence of the PIERCE1 expression between mice and humans as a p53 target gene.

PIERCE1, p53 induced expression 1 in Rb null cells, is a novel p53 target involved in the DNA damage response and cell cycle in mice. These facts prompted us to study the function of PIERCE1 with respect to p53-associated pathophysiology of cancer in humans. Unexpectedly, PIERCE1 did not respond to...

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Bibliographic Details
Main Authors: Hye Jeong Kim, Seung Eon Lee, Heeju Na, Jae-Seok Roe, Jae-Il Roh, Han-Woong Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0236881