Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in R139C
Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients who are NUDT15 poor metabolizers and consider...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Yeungnam University College of Medicine
2020-10-01
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| Series: | Yeungnam University Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.e-yujm.org/upload/pdf/yujm-2020-00178.pdf |