Troglitazone Inhibits Vascular Endothelial Growth Factor–Induced Angiogenic Signaling via Suppression of Reactive Oxygen Species Production and Extracellular Signal–Regulated Kinase Phosphorylation in Endothelial Cells
Thiazolidinediones, peroxisome proliferators-activated receptor gamma (PPARγ) ligands, have been recognized as a potential therapeutic agents for the treatment of pathological neovascularization. In the present study, we examined the molecular mechanism by which troglitazone (TROG), a PPARγ agonist,...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-01-01
|
| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319311284 |