Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas.

Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas.

Activating c-KIT mutations (exons 11 and 17) are found in 10-40% of testicular seminomas, the majority being missense point mutations (codon 816). Malignant ovarian dysgerminomas represent ~3% of all ovarian cancers in Western countries, resembling testicular seminomas, regarding chromosomal aberrat...

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Bibliographic Details
Main Authors: Remko Hersmus, Hans Stoop, Gert Jan van de Geijn, Ronak Eini, Katharina Biermann, J Wolter Oosterhuis, Catharina Dhooge, Dominik T Schneider, Isabelle C Meijssen, Winand N M Dinjens, Hendrikus Jan Dubbink, Stenvert L S Drop, Leendert H J Looijenga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3429439?pdf=render

Internet

http://europepmc.org/articles/PMC3429439?pdf=render

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