Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats

The triggers and pathogenesis of peripheral diabetic neuropathy are poorly understood, and this study evaluated the role of insulinopenia in nociceptive abnormalities in the streptozotocin (STZ) rat model of diabetes to test the hypothesis that, in addition to hyperglycemia, impairment of insulin si...

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Bibliographic Details
Main Authors: Dmitry Romanovsky, Nancy F. Cruz, Gerald A. Dienel, Maxim Dobretsov
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001768