Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression.

Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression.

Most clinical MRSA (methicillin-resistant S. aureus) isolates exhibit low-level β-lactam resistance (oxacillin MIC 2-4 μg/ml) due to the acquisition of a novel penicillin binding protein (PBP2A), encoded by mecA. However, strains can evolve high-level resistance (oxacillin MIC ≥256 μg/ml) by an unkn...

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Bibliographic Details
Main Authors: Viralkumar V Panchal, Caitlin Griffiths, Hamed Mosaei, Bohdan Bilyk, Joshua A F Sutton, Oliver T Carnell, David P Hornby, Jeffrey Green, Jamie K Hobbs, William L Kelley, Nikolay Zenkin, Simon J Foster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008672

Internet

https://doi.org/10.1371/journal.ppat.1008672

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