Asiaticoside inhibits TGF-β1-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5

Asiaticoside inhibits TGF-β1-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5

Abstract Background Peritoneal fibrosis (PF) is a frequent complication caused by peritoneal dialysis (PD). Peritoneal mesothelial cells (PMCs), the first barrier of the peritoneum, play an important role in maintaining structure and function in the peritoneum during PD. Mesothelial-mesenchymal tran...

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Bibliographic Details
Main Authors: Junyi Zhao, Jun Shi, Yun Shan, Manshu Yu, Xiaolin Zhu, Yilin Zhu, Li Liu, Meixiao Sheng
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
Human peritoneal mesothelial cells (HPMCs)
Mesothelial-mesenchymal transition (MMT)
Reactive oxygen species (ROS)
TGF-β/Smad
Nrf-2/HO-1
Online Access:http://link.springer.com/article/10.1186/s11658-020-00226-9

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http://link.springer.com/article/10.1186/s11658-020-00226-9

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