Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Abstract Background Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased. As they exhibit fewer side effects and food interactio...

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Bibliographic Details
Main Authors: Priyanka Dhiman, Neelam Malik, Anurag Khatkar
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Chemistry Central Journal
Subjects:
Monoamine oxidase
In silico design
Caffeic acid derivatives
DPPH and H2O2 activity
Online Access:http://link.springer.com/article/10.1186/s13065-018-0481-7

Internet

http://link.springer.com/article/10.1186/s13065-018-0481-7

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