Is there an epigenetic component underlying the resistance of triple-negative breast cancers to PARP inhibitors?

Is there an epigenetic component underlying the resistance of triple-negative breast cancers to PARP inhibitors?

Poly(ADP-ribose)polymerase (Parp) is an enzyme responsible for catalyzing post-translational modifications through the addition of poly(ADP-ribose) chains (known as PARylation). Modification by PARylation modulates numerous cellular processes including transcription, chromatin remodeling, apoptosis...

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Bibliographic Details
Main Authors: Amanda eLovato, Lawrence ePanasci, Michael eWitcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Pharmacology
Subjects:
Transcription Factors
epigenetics
breast cancer
therapeutic resistance
PARP inhibitors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00202/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00202/full

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