Protein Phosphorylation and Mineral Binding Affect the Secondary Structure of the Leucine-Rich Amelogenin Peptide

Previously, we have shown that serine-16 phosphorylation in native full-length porcine amelogenin (P173) and the Leucine-Rich Amelogenin Peptide (LRAP(+P)), an alternative amelogenin splice product, affects protein assembly and mineralization in vitro. Notably, P173 and LRAP(+P) stabilize amorphous...

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Bibliographic Details
Main Authors: Hajime Yamazaki, Elia Beniash, Yasuo Yamakoshi, James P. Simmer, Henry C. Margolis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00450/full