Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients

Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients

T cells play a critical role in coronavirus diseases. How they do so in COVID-19 may be revealed by analyzing the epigenetic chromatin accessibility of cis- and trans-regulatory elements and creating transcriptomic immune profiles. We performed single-cell assay for transposase-accessible chromatin...

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Bibliographic Details
Main Authors: Shun Li, Bin Wu, Yun Ling, Mingquan Guo, Boyin Qin, Xiaonan Ren, Chao Wang, Hua Yang, Lixiang Chen, Yixin Liao, Yang Liu, Xiuhua Peng, Chunhua Xu, Zhenyan Wang, Yinzhong Shen, Jun Chen, Li Liu, Bowen Niu, Mengmin Zhu, Lingling Liu, Feng Li, Tongyu Zhu, Zhaoqin Zhu, Xiaohui Zhou, Hongzhou Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
chromatin accessibility
transcriptome profiling
scATAC-seq
ScRNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.625881/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.625881/full

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