Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment

Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment

Abstract Background Epiregulin (EREG) is an important component of EGF and was demonstrated to promote the osteo/dentinogenic differentiation of stem cells from dental apical papilla (SCAPs). Whether EREG can stimulate the osteo/dentinogenic differentiation of dental pulp stem cells (DPSCs) in infla...

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Bibliographic Details
Main Authors: Ran Ran, Haoqing Yang, Yangyang Cao, Wanhao Yan, Luyuan Jin, Ying Zheng
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Oral Health
Subjects:
Epiregulin (EREG)
Dental pulp stem cells (DPSCs)
Osteo
Dentinogenic differentiation
TNF-α
Inflammatory environment
Online Access:https://doi.org/10.1186/s12903-021-01675-0

Internet

https://doi.org/10.1186/s12903-021-01675-0

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