Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

Background: Reduced activation of dopamine D1 receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highly expressed in the striatum, modulates both dopamine D2- and D1-dependent signa...

Full description

Bibliographic Details
Main Authors: Daniel Umbricht, Markus Abt, Paul Tamburri, Christopher Chatham, Štefan Holiga, Michael J. Frank, Anne G.E. Collins, David P. Walling, Rick Mofsen, Daniel Gruener, Lev Gertsik, Jeff Sevigny, Sanjay Keswani, Juergen Dukart
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Biological Psychiatry Global Open Science
Subjects:
Negative symptoms
PDE10 inhibitor
Proof-of-mechanism study
Reward functioning
RG7203
Schizophrenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174321000033

Internet

http://www.sciencedirect.com/science/article/pii/S2667174321000033

Similar Items