Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells

Targeted intracellular protein degradation in eukaryotes is largely mediated by the proteasome. Here, we report the formation of an alternative proteasome isoform in human cells, previously found only in budding yeast, that bears an altered subunit arrangement in the outer ring of the proteasome cor...

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Bibliographic Details
Main Authors: Achuth Padmanabhan, Simone Anh-Thu Vuong, Mark Hochstrasser
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716302030