Role of duplicate genes in robustness against deleterious human mutations.

It is now widely recognized that robustness is an inherent property of biological systems [1],[2],[3]. The contribution of close sequence homologs to genetic robustness against null mutations has been previously demonstrated in simple organisms [4],[5]. In this paper we investigate in detail the con...

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Bibliographic Details
Main Authors: Tzu-Lin Hsiao, Dennis Vitkup
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2265532?pdf=render